LINA @ UofSC

LINA @ UofSC

Principled, model-driven approaches for multi-scale analysis of the brain.

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Funded projects

Model-driven analysis of autonomic control in ASD using ECG

Funding : CAN Pilot Grant ($40,000)

Dates : 6/2022-6/2023

Investigators : Christian O’Reilly (PI), Xiaoxue Fu (Co-PI), Jessica Bradshaw (Co-I), Jane Roberts (Co-I)

Description : This project aims to develop a more principled approach to the study of the autonomous nervous system (ANS) from electrocardiograms (ECG). We expect to improve our understanding of the impact of ASD on ANS physiology by more accurately modeling the cardiac processes. We will achieve this objective by injecting in our analyses prior knowledge captured by 1) the model structure and 2) prior distributions for model parameters. Specific we aim to 1) formulate and validate a heart model simulating the heart response to an input control signal representing the ANS tonus (forward modeling); 2) implement Bayesian inference of model parameters and control signals from ECG recordings (inverse modeling); and develop and compare across clinical groups growth curves describing the evolution of model parameters (growth curves).

Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualization

Funding : NIMH R01 ($2,105,720)

Dates : 7/2023-06/2026

Investigators : Chris Rorden (PD/PI), Roger Newman-Norlund (Co-PD/PI), Alex Teghipco (Co-I), Christian O’Reilly (Co-I), Rutvik H Desai (Co-I), Franco Pestilli (key personnel)

Description : Develop and refine software to visualize and analyze the data from the BRAIN Initiative. Tasks: 1) Extend ezBIDS to improve intention prediction, make defacing more robust, provide visual confirmation for automated steps and ease anonymized data transfer. 2) Provide a modern desktop-based interface for interacting with AFNI. 3) Provide a cloud-based solution for configuring image processing and analyses and inspecting the results. 4) The jupyter notebook based ipyNiiVue will provide Python-based visualization.

Cholinergic regulation of amygdalar circuits in emotional memory

Funding : NIMH R01 ($3,364,926)

Dates : 7/2023-6/2028

Investigators : Davit Mott (PI), Aaron Jasnow (Co-I), Christian O’Reilly (Co-I)

Description : This proposal will directly examine the role of released ACh in regulating BLa circuits and emotional behaviors. Aim 1. To determine the circuit mechanism by which synaptic acetylcholine modulates local BLa oscillations. Aim 2: To determine the mechanism by which ACh acts on the BLa circuit to regulate fear learning. Aim 3: To determine the circuit mechanism by which ACh regulates fear discrimination.

The Role of Autonomic Regulation of Attention in the Emergence of ASD

Funding : NIMH R01 ($3,732,820)

Dates : 4/2023-3/2028

Investigators : Jessica Bradshaw (PI), Dail Robin (Co-I), Jana M Iverson (Co-I), Christian O’Reilly (Co-I), John E Richard (Co-I), Jane E Roberts (Co-I)

Description : This work will inform developmental models of ASD wherein disrupted autonomic regulation of attention has proximal effects on real-world interactions that may interfere with learning and have cascading effects on long-term outcomes.